The Barriault Research Group

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Publications


  1. Hébert, M., Bellavance, G., Barriault, L. Advanced Synthetic Strategies toward Ginkgolide Diterpenoids: Total Synthesis of (±)-Ginkgolide C and Formal Syntheses of (±)-Ginkgolides A and B J. Org. Chem. 2025,  ASAP.

Zidan

 


  1. Morris, A., O’Brien, T.E., Barriault, L. Photoredox-Catalyzed Hydroalkylation of C(sp3)-H Acids Chem. Eur. J. 2025,  27, e202501148.

Zidan

 


  1. Montserrat, Z., Villela, L. F., Barriault, L. Photoactivated Formal [3 + 2] / [4+2] Cycloaddition of N-Aryl Cyclopropyl and Cyclobutylamines Chem. Eur. J. 2024,  27, e202400558.

Zidan

 


  1. Morris, A. O., Barriault, L. Redox-Neutral Multicatalytic Cerium Photoredox-Enabled Cleavage of O–H Bearing Substrates Chem. Eur. J. 2024,  e202400642

Morris

 


  1. Tibouti, S., Barriault, L. An Overview of Syntheses of Salvinorin A and its Analogues Chem. Cat. Chem 2024,  e202400182

Tibouti

 


  1. O’Brien, T.E., Morris, A.O., Villela, L. F., Barriault, L. Synthetic Applications of Photochemically Generated Radicals from Protic C(sp3)–H Bonds Chem. Cat. Chem 2023,  e202300989

OBrien

 


  1. Tran, H.; McGee, P., Barriault, L. Formal Synthesis of (±)-Salvinorin A via Gold(I) Catalysis Chem. Eur. J. 2023,  e202301640

hebert

 


  1. Barriault, L.; Hébert, M., Bellavance, G. Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B J. Am. Chem. Soc., 2022, 144, 17702-17796.

hebert

 


  1. Barriault, L.; Tran, H.; Revol, G.; Poyser, A. Divergent and Modular Synthesis of Terpenoid Scaffolds via a Au(I) Catalyzed One-Pot Cascade Angew. Chem. Int. Ed, 2022, 61, e202110575.

htran

 


  1. Barriault, L.; Zidan, M.; McCallum, T.; Swann, R.; Formal Bromine Atom Transfer Radical Addition of Nonactivated Bromoalkanes Using Photoredox Gold Catalysis Org. Lett., 2020, 22, 8401-8406.

montse2

 


  1. Barriault, L.; Rohe, S.; Révol, G.; Marmin, T.; Barriault, D.; Barriault, L.; Single-Electron Transfer from Dimsyl Anion in the Alkylation of Phenols J. Org. Chem., 2020, 85, 2806-2813.

sam2020

 


  1. Barriault, L.; Zidan, M.; Morris, A.O.; McCallum, T.; The Alkylation and Reduction of Heteroarenes with Alcohols Using Photoredox Catalyzed Hydrogen Atom Transfer via Chlorine Atom Generation Eur. J. Org. Chem., 2020, 1453-1458.

montse


  1. Barriault, L.; Brousseau, J.; Xiolin A.; A Nine-Step Formal Synthesis of (±)-Morphine Org Lett., 2019, 21, 1347-1349.

julie


  1. Barriault, L.; Zidan, M.; Rohe, S.; McCallum, T.; Recent Advances in Mono and Binuclear Gold Photoredox Catalysis Catal. Sci. Technol., 2018, 8, 6019-6028.

monste review


  1. Barriault, L.; Rohe, S.; Morris, A.O.; McCallum, T.; Hydrogen Atom Transfer Reactions via Photoredox Catalyzed Chlorine Atom Generation Angew. Chem, Int. Ed. 2018 57, 15664-15669.

sam 2018 2


  1. Barriault, L.; Rohe, S.; McCallum, T.; Morris, A.O., Transformations of Isonitriles with Bromoalkanes using Photoredox Gold Catalysis J. Org. Chem. 2018, 83, 10015-10024

samavery


  1. Barriault, L.; Bellavance, G., Modular Total Syntheses of Hyperforin, Papuaforins A, B and C via Gold(I)-Catalyzed Carbocyclization (Article) J. Org. Chem. 2018 83, 7215–7230

gab-2014


  1. Barriault, L.; McGee, P.; Brousseau, J., Development of New Gold (I)-Catalyzed Carbocyclizationsand their Applications in the Synthesis of Natural Products.  Isr. J. Chem. 2017, 57, 1-11

julie phil


  1. Barriault, L.; McCallum, T.; Pitre, S. P.; Morin, M.; Scaiano, J. C., The Photochemical Alkylation and Reduction of Heteroarenes. Chemical Science 2017, 8, 7412-7418.

terry 2017


  1. L. Barriault, M. Zidan, T. McCallum, L. Thai-Savard. Photoredox Meets Gold Lewis Acid Catalysis in the Alkylative Semipinacol Rearrangement: A Photocatalyst with a Dark Side. Org. Chem. Front. 2017, 4, 2092-2096.

Graphical Abstracts


  1. Barriault, L.; McGee, P.; Bétournay, G.; Barabé, F. An 11-Step Total Synthesis of Magellanine through a Gold(I)-Catalyzed Dehydro Diels-Alder Reaction. Angew. Chem. Int. Ed. 2017, 56, 6280–6283.
    phil-2016

     


  2. McCallum, T.; Rohe, S.; Barriault, L. Thieme Chemistry Journals Awardees – Where Are They Now? What’s Golden: Recent Advances in Organic Transformations Using Photoredox Gold Catalysis. Synlett. 2016, 27, A-Q (account)sam

  3. Barriault, L.; Tran, H.; McCallum, T.; Morin, M. Homocoupling of Iodoarenes and Bromoalkanes Using Photoredox Gold Catalysis: A Light Enabled Au(III) Reductive Elimination. Org Lett. 2016, 18, 4308.

huy


  1. Barriault, L.; Cannillo, A.; Schwantje, T. R.; Bégin, M., Barabé, F. Gold-Catalyzed Photoredox C(sp2) Cyclization: Formal Synthesis of (±)-Triptolide. Org Lett. 2016, 18, 2592.Abstract Image

  2. Barriault, L.; McCallum, T. Direct Alkylation of Heteroarenes with Unactivated Bromoalkanes using Photoredox Gold Catalysis. Chem. Sci. 2016, 7, 4754.Graphical abstract: Direct alkylation of heteroarenes with unactivated bromoalkanes using photoredox gold catalysis

  3. Barriault, L.; McCallum, T.; Jouanno, L.-A.; Cannillo, A. Persulfate-Enabled Direct C–H Alkylation of Heteroarenes with Unactivated Ethers. Synlett. 2016, 27, 1282.terry-2015

  4. Barriault, L.; Scaiano, J. C.; McTiernan, C. D.; Morin, M.; McCallum, T. Polynuclear Gold(I) Complexes in Photoredox Catalysis: Understanding their Reactivity throught Characterization and Kinetic Analysis. Cat. Sci. Technol., 2016, 6, 201.Graphical abstract: Polynuclear gold(i) complexes in photoredox catalysis: understanding their reactivity through characterization and kinetic analysis

  5. Barriault, L.; Kaldas, S. J.; Cannillo, A.; McCallum, T. Indole Functionalization via Photoredox Gold Catalysis. Org Lett. 2015, 17, 2864.Abstract Image

  6. Barriault, L.; McGee, P.; Bellavance G.; Korobkov, I.; Tarasewicz, A. Synthesis and Isolation of Organogold Complexes via a Controlled 1,2-Silyl Migration. Chem. Eur. J. 2015, 21, 9662.phil-2015

  7. Barriault, L.; McCallum, T. Light-Enabled Synthesis of Anhydrides and Amides, J. Org. Chem. 2015, 80, 2874.Abstract Image

  8. Barriault, L.; McCallum, T.; Morin, M.; Slavko, E. Light-Mediated Deoxygenation of Alcohols with a Dimeric Gold Catalyst. Eur. J. Org. Chem. 2015, 81.deoxygenation-scheme

  9. Barriault, L.; Bellavance, G. Total Syntheses of Hyperforin, Papuaforins A-C and Formal Synthesis of Nemorosone via a Gold(I)-Catalyzed Carbocyclization. Angew. Chem, Int. Ed. 2014, 53, 6701.gab-2014

  10. Barriault, L.; Morin, M.; Levesque, P. Gold(I)-Catalyzed Domino Cyclizations for the Synthesis of Polyaromatic Heterocycles. Beils. J. Org. Chem. 2013, 9, 2625.matpat

  11. Barriault, L.; Revol, G.; McCallum, T.; Morin, M.; Gagozs, Photoredox Transformations via Gold Dimeric Complexes. Angew Chem, Int. Ed. 2013, 52, 13342.

terry-2013


  1. Barriault, L.; Barabé, F.; Levesque, P.; Bellavance, G.; Sow, B., Gold-Catalyzed Synthesis of Bridged and Fused Carbocyles, Pure and Appl. Chem. 2013, 85, 1161.francis-2013

  2. Barriault, L.; Denissova, I,; Goulet, N. Mechanistic Investigation of the Domino Oxy-Cope/Claisen/Ene Reaction and its Application to the Synthesis of Desdimethyl Ambiol B. Synthesis, 2012, 44, 1833. (invited contribution to a special issue on domino reaction, Ed. E. M. Carreira)https://www.thieme-connect.de/media/synthesis/201212/c0291_ga.gif

  3. Barriault, L.; Poulin, J, Grisé-Bard, C.M. Formal Synthesis of Vinigrol. Angew. Chem. Int., Ed 2012, 51, 2111. (VIP)vinigrol

  4. Barriault, L. ; Barabé, F.; Levesque, P.; Korobkov. I. Synthesis of Fused Carbocycles via a Selective 6-endo dig Gold(I)-Catalyzed Carbocyclization. Org. Let. 2011, 13, 5580.Abstract Image

  5. Barriault, L. ; Sow, B.; Bellavance, G.; Barabé, F. Concise Synthesis of Bridgehead Ketone via Domino Gold-Catalyzed Cyclizations. Beils. J. Org. Chem. 2011, 7, 1007. (Invited contribution for a special issue in gold-catalyzed process)1860-5397-7-114

  6. Barriault, L.; Woo. T.; Hooper, J.; Sauer, E. L. O., On the Origin of Altered Diastereomeric Ratios for Anionic versus Neutral Reaction Conditions in the Tandem Oxy-Cope/Claisen/Ene. Eur. Chem. J. 2010, 16, 14124.msch001

  7. Barriault, L. ; Beingessner, R. ; Farand, J., Toward the Synthesis of Havellocakte. J. Org. Chem. 2010, 75, 6337 (Feature Article)Abstract Image

  8. Barriault, Barabé, F.; Bétournay, G.; Bellavance G. Gold(I)-Catalyzed Synthesis of Carbon Bridged-Medium Sized Rings. Org. Lett. 2009, 11, 4236. (communication)Abstract Image

  9. Barriault, Grisé-Bard, C. M.; Poulin J. Pericyclic Domino Reactions : Consise Approaches to Natural Carbocyclic Frameworks. Chem. Rev. Soc. 2009, 38, 3092. (review)Graphical abstract: Pericyclic domino reactions: concise approaches to natural carbocyclic frameworks

  10. Barriault, L.; Riou, M. De Novo Synthesis of (+)-Isofregenedol. J. Org. Chem 2008, 73, 7436.maxime-2007

  11. Barriault, L.; Clément, R.; Grisé, C. M. Stereocontrolled Synthesis of Carbocycles via Four Successive Pericyclic Reactions. Chem. Comm. 2008, 3004. (communication)Graphical abstract: Stereocontrolled synthesis of carbocyclesvia four successive pericyclic reactions

  12. Barriault, L.; Grisé, C. M.; Rodrigue, E. M. Gold(I)-Catalyzed Benzannulation of 3-Hydroxy-1,5-Enynes: An Efficient Synthesis of Substituted Tetrahydronaphthalenes and Related Compounds. Tetrahedron, 2008, 64, 797. (Symposium-in-Print)

  13. Barriaut, L.; Arns, S.; Lebrun, M. E.; Grisé, C. M.; Denissova, I. Diastereoselective Construction of Quaternary Carbons Via Macrocyclic Conformation. Formal Synthesis of (-)-Mesembrine. J. Org. Chem. 2007, 72, 9314. (article)Abstract Image

  14. Barriault, L.; Tessier, G. The Conquest of Vinigrol: Creativity, Frustrations and Hope. Org. Prep. Proc. Int. 2007, 39, 311. (review)

  15. Barriault, L.; Grisé, C. M.; Tessier, G. Synthesis of the Tricyclic Core of Vinigrol via Intramolecular Diels-Alder Reaction. Org. Lett. 2007, 9, 1545. (communication)Abstract Image

  16. Barriault, L.; Arns, S. Cascading Pericyclic Reactions: Building Complex Carbon Frameworks For Natural Product Synthesis. Chem. Comm. 2007, 2211. (feature article)Graphical abstract: Cascading pericyclic reactions: building complex carbon frameworks for natural product synthesis

  17. Barriault, L.; Sauer, E. L. O.; Hooper, J.; Woo, T. The Origin of Diastereoselectivity in the Tandem Oxy-Cope/Claisen/Ene Reaction: Experimental and Theoretical Studies of the Ring Inversion Mechanism. J. Am. Chem. Soc. 2007, 129, 2112. (article)Abstract Image

  18. Barriault, L.; Grisé, C. M. Gold-Catalyzed Synthesis of Substituted Tetrahydronaphthalenes Org. Lett. 2006, 8, 5905. (communication)Abstract Image

  19. Barriault, L.; Arns, S. A Concise Synthesis of the Neo-Clerodane Skeleton of Teucrolivin A Using An Oxy-Cope/Claisen/Ene Cascade. J. Org. Chem. 2006, 71, 1809. (article)Abstract Image

  20. Barriault, L.; Lavigne, R. M. A.; Riou, M.; Girardin, M.; Morency, L. Synthesis of Highly Functionalized Bicyclo[m.n.1]alkanones via a Cationic Reaction Cascade. Org. Lett. 2005, 7, 5921. (communication)Abstract Image

  21. Barriault, L.; Warrington, J. M. Synthesis of the C7-C15 trans Decalin Portion of Natural Antibiotic Tetrodecamycin. Org. Lett. 2005, 7, 4589. (communication)Abstract Image

  22. Barriault, L.; Morency, L. Studies Toward the Total Synthesis of Vinigrol. Synthesis of the Octalin Ring. J. Org. Chem. 2005, 70, 8841. (article)Abstract Image

  23. Barriault, L.; Gauvreau, D. Conservation of Planar Chirality in the Tandem Oxy-Cope/Ene Reaction. J. Org. Chem. 2005, 70, 1382. (article)Abstract Image

  24. Barriault, L.; Sauer, E. L. O. Stereoselective Synthesis of Quaternary Stereocenters: Asymmetric Cross-Coupling and Heck Reactions, 2005, 185-204. Book Chapter (invited contribution).

  25. Barriault, L.; Sauer, E. L. O. Studies Toward the Synthesis of Wiedemannic acid. Org. Lett. 2004, 6, 3329. (communication)Abstract Image

  26. Barriault, L.; Morency, L. Stereoselective Synthesis of the cis-Decalin Subunit of Vinigrol via a Three Pericyclic Reactions in Cascade. Tetrahedron Lett. 2004, 45, 6105. (communication)image

  27. Barriault, L; Sauer, E. L. O. Highly Efficient Transfer of Chirality from Macrocyclic Conformation in the Tandem Oxy-Cope/ Claisen/Ene Reaction. J. Am . Soc. Chem. 2004, 126, 8569. (article)Abstract Image

  28. Barriault, L.; Ang, P. A. J.; Lavigne, R. M. A. Rapid Assembly of the Bicyclo[5.3.1]undecenone Core of Penostatin F: a Successive Diels-Alder/Claisen Reaction Strategy with an Efficient Stereochemical Relay. Org. Lett. 2004, 6, 1317. (communication)Abstract Image

  29. Barriault, L.; Farand, J. A.; Denissova, I. Microwave Assisted Pericyclic Reaction in Cascade to Construct Decalin Frameworks Possesing Quaternary Centers. Scope and Limitations. Heterocycles 2004, 62, 735. (article) (invited contribution honoring Leo Paquette).

  30. Barriault, L.; Denissova, I. Stereospecific Synthesis of Quaternary Carbon Centers and Related Functions. Tetrahedron 2003, 59, 10105. (review)

  31. Barriault, L; Thomas, J.D.; Clément, R. Highly Stereoselctive Hydroxy-Directed Diels-Alder Reaction. J. Org. Chem. 2003, 68, 2317. (article)Abstract Image

  32. Barriault, L.; Denissova, I. Highly Diastereoselective synthesis of Decalin Skeletons with Quaternary Carbon Centers Using the Tandem Oxy-Cope/Ene/Claisen Reaction. Org.Lett. 2002, 4, 1371. (communication)Abstract Image

  33. Barriault, L.; Deon, D.H. Total Synthesis of (+)-Arteannuin M Using the Tandem Oxy-Cope/Ene Reaction. Org. Lett. 2001, 3, 1925. (communication)Abstract Image

  34. Fortin, S.; Barriault, L.; Dory, Y. L.; Deslongchamps,P. Transannular Diels-Alder Reaction of a TTC Macrocycle Having an Activating Dienophile. An Enantioselective Synthesis of ABC [6.6.6] Trans-Syn-Trans and Trans-Anti-Cis Tricycles. J. Am .Chem. Soc. 2001, 123, 8210. (article)

  35. Barriault, L.; Warrington, J. M. and Yap, G. P. A. Tandem oxy-Cope/Ene Reaction of 1,2-Divinylcyclohexanols. Org. Lett. 2000, 2, 663. (communication)Abstract Image

  36. Paquette, L. A.; Barriault, L.; Pissarnitski, D.; Johnston, J. N. Stereocontrolled Elaboration of Natural (-)-Polycavernoside A, a Powerfully Toxic Metabolite of the Red Alga Polycavernosa Tsudai. J. Am. Chem. Soc. 2000, 122, 619. (article)louis

  37. Barriault, L.; Boulet, S. L.; Fujiwara, K.; Murai, A.; Paquette, L. A.; Yotsu-Yamashita M. Synthesis and Biological Evaluation of Analogues of the Marine Toxin Polycavernoside A. Bioorg. Medicin. Chem. Lett. 1999, 9, 2069. (communication)

  38. Barriault, L.; Paquette, L. A. The first Total Syntheses of Ircinol A, Ircinal A and Manzamines A and D. Chemtracts 1999, 12, 276. (review)

  39. Paquette, L. A.; Barriault, L.; Pissarnitski, D. A Convergent Total Synthesis of the Macrolactone Disacharide Toxin (-)- Polycavernoside A. J. Am. Chem. Soc. 1999, 121, 4542. (communication)

  40. Paquette, L. A., Pissarnitski, D.; Barriault, L.A Modular Enantioselective Approach to Construction of the Macrolactone Core of Polycavernoside A. J. Org. Chem. 1998, 63, 7389. (article)Abstract Image

  41. Barriault, L.; Deslongchamps, P. Synthesis of 17-Membered Ring Macrocyle: Studies Toward the Enantioselective Synthesis of Fusidic Acid. Bull. Soc. Chim. Fr. 1997, 134, 969. (article)

  42. Barriault, L.; Ouellet, S. G.; Deslongchamps, P. Transannular Diels-Alder reaction Studies with an Activated Dienophile. An Enantioselective Synthesis of an ABC [6.6.6] Trans-Syn-Cis Tricycle. Tetrahedron 1997, 53, 14937. (article)Image for unlabelled figure